It is unclear however whether the relationship between global cognitive function and walking capacity favours male or female sex. Age-associated changes in physical function ( 21, 22) can compromise the ability for older adults to engage in physical activity ( 23), potentially contributing to further declines in cognitive and functional capacity.īiological sex may moderate the relationship between cognitive and physical function, as it strongly influences aging-related processes, as well as the prevalence, diagnosis, severity, and outcomes of disease ( 24). With increasing age, declines in cognition ( 18) and walking capacity ( 19), as well as higher prevalence of chronic conditions such as stroke ( 20), often occur. Conversely, greater walking capacity has been shown to have moderate to strong correlations with global cognitive function ( 7– 14), memory ( 8, 9, 15), attention ( 9, 14, 16), verbal fluency ( 9, 14), and executive function ( 9, 14, 17) in older adults with ( 6– 11, 15– 17) and without ( 12– 14) chronic conditions. Cognitive function is known to be associated with physical function. It can impact performance of activities of daily living ( 2), and increase the risk of depression, apathy, irritability, lowered quality of life ( 3), and cardiovascular disease ( 4, 5). Mild cognitive impairment is present in approximately 40% of older adults worldwide ( 1). Notably, we also observed superior performance in global cognition among females that was consistent across a broad spectrum of walking capacity. When adjusting for age, height and history of stroke, males MoCA scores were 2.9 ± 1.3 less than the mean MoCA scores for females.ĭiscussion: Our findings confirm the positive relationship between cognitive and physical function in older adults. No interaction with sex was found, but a main effect of sex was observed ( R 2 = 0.26 F(5,21) = 3.72 p = 0.03). Our sample represented broad ranges of cognitive and physical function levels, where MoCA scores ranged from 13 to 30, and 6 MWT distances from 203 to 750 m. Results: Twenty-three females and 36 males were included in the multivariable regression analyses, respectively. To determine if there were sex-based differences in the association between global cognitive function and walking capacity, we included sex and an interaction term between sex*6 MWT distance in Models 3 and 4. First, we presented the unadjusted model (Model 1), then the model adjusted for age, history of stroke, and height (Model 2). Multivariable regression analyses were performed to examine the interaction of sex in the association between MoCA and 6 MWT. Methods: Participants were assessed for global cognitive function (MoCA) and walking capacity (6 MWT). The purpose of this study was to examine the associations between global cognitive function (Montreal Cognitive Assessment MoCA), walking capacity (6-Minute Walk Test distance 6 MWT) and sex in an aging population with broad ranges of cognitive and physical function. Biological sex may moderate the relationship between cognitive and physical function, but whether sex differences exist in this association has not been examined in an aging population. Introduction: Cognitive function is known to be associated with physical function, where greater walking capacity has been shown to have moderate to strong correlations with global cognitive function and other various domains of cognition in older adults with and without chronic conditions. 6School of Physical / Occupational Therapy, McGill University, Montreal, QC, Canada.5Memory and Motor Rehabilitation Laboratory (MEMORY-LAB), Feil and Oberfeld Research Centre, Jewish Rehabilitation Hospital, Montreal Center for Interdisciplinary Research in Rehabilitation, Laval, QC, Canada.4School of Physical Therapy, Western University, London, ON, Canada.3Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Science, University of British Columbia, Kelowna, BC, Canada.2Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands.1School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.MacDermid 1,4 Lynden Rodrigues 5,6 Marc Roig 5,6 Ada Tang 1* Shkredova 2,3 Hanna Fang 1 Julie Richardson 1 Joy C. Noguchi 1 Kevin Moncion 1 Natalie D’Isabella 1 Daria A.
0 kommentar(er)
